21c Museum Hotel Lexington

21c Museum Hotel Lexington occupies the landmark 1914 Fayette National Bank building in the heart of downtown Lexington, Kentucky — a boutique hotel, contemporary art museum, and event destination under one roof. The building's original architectural character, including its historic windows and high ceilings, lends a distinctive backdrop to weddings, corporate gatherings, and private celebrations. The hotel's free, 24/7 contemporary art museum sets it apart: rotating and site-specific exhibitions fill the galleries that also double as event spaces, making every gathering feel immersive in a way a standard ballroom cannot replicate. Seven thousand square feet of art-filled gallery and meeting space accommodates groups from intimate boardroom sessions to receptions of up to 250 guests. Lockbox, the hotel's restaurant, provides chef-driven catering for on-site events, drawing on local flavors. Whether hosting a rehearsal dinner in the private dining room, a wedding reception in the main gallery, or a multi-day corporate retreat, 21c Lexington brings together distinctive architecture, contemporary art, and custom culinary offerings in a single downtown location.