Tsali Notch Vineyard

Named for a historic Cherokee leader, Tsali Notch Vineyard is a working vineyard and winery tucked into the foothills of Madisonville, Tennessee, within the Tennessee Overhill Heritage Area and along the route to the Cherohala Skyway. The 202-acre estate is planted with more than 6,000 muscadine vines across 21 miles of trellis, with the Great Smoky Mountains rising in the distance — a setting the vineyard describes as an idyllic backdrop for its wines and its events alike. As Tennessee's largest muscadine grape producer, the vineyard is known for award-winning wines crafted from "America's Wild Grape," grown without chemicals across six varieties. Beyond wine tastings, Tsali Notch hosts weddings, receptions, reunions, and civic gatherings across several venue spaces: the picturesque vineyard grounds, the Vineyard Tasting Room for intimate gatherings, the Upper Barn for larger celebrations, and the Jackson Lounge, a lovingly restored 19th-century farmhouse offering a more relaxed atmosphere. Each fall, the vineyard opens its rows to the public for muscadine picking, drawing visitors out among the vines to harvest grapes for wine, juice, or jelly — a seasonal tradition that reflects the vineyard's blend of rustic charm and working agricultural heritage.